产品
编 号：F070101
分子式：C14H12O2
分子量：212.24
分子式：C14H12O2
分子量：212.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
500mg
1200
In-stock
结构图
CAS No: 120-51-4
产品详情
生物活性：
Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.
体内研究：
Benzyl benzoate (25-100 mg/kg; 口服; 一天一次，连续 90 天) 在 Sprague Dawley 大鼠中对大鼠的体重、相对器官重量、血液学和生化结果没有显著影响，但会引起肝、肾、胸腺、前列腺和附睾组织发生病理变化。Benzyl benzoate (2-10 mg/kg; 口服; 单剂量) 在 Std:ddY小鼠中可以显著抑制 Ang II (100 μg/kg) 诱导的高血压。Animal Model:Hypertensive male Std:ddY mice model
Dosage:2 mg/kg, 10 mg/kg
Administration:Oral gavage (p.o.); Single dose. Before Ang II treatment (100 μg/kg; Intraperitoneal injection (i.p.); Single dose)
Result:Significantly inhibited the rise in systolic blood pressure induced by Ang II treatment.
Animal Model:Sprague Dawley male rats model
Dosage:25 mg/kg, 100 mg/kg
Administration:Oral gavage (p.o.); Once daily for 90 days
Result:Induced hepatic portal vein blood supply, sinusoid sinus enlargement, monocyte infiltration, local lysis and cytoplasmic degeneration in rats.Induced renal tissue congestion, renal tubule degeneration, monocyte infiltration and histolysis in rats.Resulted in increased number of Hassall’s bodies, elevated lipids, degeneration, congestion, fibrosis and lymphocytopenia in the thymus of rats.Resulted in vacuolation and irregular secretion of the prostate in male reproductive system tissue, increased connective tissue of the epididymis and presence of cells in the lumen.In the male reproductive system tissues, resulted in vacuolation and irregular secretion in the prostate, increased connective tissue of the epididymis, and presence of cells in the lumen.
体外研究：
Benzyl benzoate (10000-50000 mg/L; 72 h) 对葱根细胞有毒性作用。Benzyl benzoate (10-100 μM; 1-200 秒) 在人胚胎肾上皮 293T (mAT1a(HA)/293T) 细胞中以剂量依赖的方式抑制 Ang II 的活性 (IC50=107 μg/mL)，且不具有细胞毒性。
Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.
体内研究：
Benzyl benzoate (25-100 mg/kg; 口服; 一天一次，连续 90 天) 在 Sprague Dawley 大鼠中对大鼠的体重、相对器官重量、血液学和生化结果没有显著影响，但会引起肝、肾、胸腺、前列腺和附睾组织发生病理变化。Benzyl benzoate (2-10 mg/kg; 口服; 单剂量) 在 Std:ddY小鼠中可以显著抑制 Ang II (100 μg/kg) 诱导的高血压。Animal Model:Hypertensive male Std:ddY mice model
Dosage:2 mg/kg, 10 mg/kg
Administration:Oral gavage (p.o.); Single dose. Before Ang II treatment (100 μg/kg; Intraperitoneal injection (i.p.); Single dose)
Result:Significantly inhibited the rise in systolic blood pressure induced by Ang II treatment.
Animal Model:Sprague Dawley male rats model
Dosage:25 mg/kg, 100 mg/kg
Administration:Oral gavage (p.o.); Once daily for 90 days
Result:Induced hepatic portal vein blood supply, sinusoid sinus enlargement, monocyte infiltration, local lysis and cytoplasmic degeneration in rats.Induced renal tissue congestion, renal tubule degeneration, monocyte infiltration and histolysis in rats.Resulted in increased number of Hassall’s bodies, elevated lipids, degeneration, congestion, fibrosis and lymphocytopenia in the thymus of rats.Resulted in vacuolation and irregular secretion of the prostate in male reproductive system tissue, increased connective tissue of the epididymis and presence of cells in the lumen.In the male reproductive system tissues, resulted in vacuolation and irregular secretion in the prostate, increased connective tissue of the epididymis, and presence of cells in the lumen.
体外研究：
Benzyl benzoate (10000-50000 mg/L; 72 h) 对葱根细胞有毒性作用。Benzyl benzoate (10-100 μM; 1-200 秒) 在人胚胎肾上皮 293T (mAT1a(HA)/293T) 细胞中以剂量依赖的方式抑制 Ang II 的活性 (IC50=107 μg/mL)，且不具有细胞毒性。
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