产品
编 号：F741285
分子式：C15H13Cl2NO3
分子量：326.17
分子式：C15H13Cl2NO3
分子量：326.17
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1808986-37-9
产品详情
生物活性：
ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC50 value of 0.6 μM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays.
体外研究：
ERCC1-XPF-IN-2 (compound 13) (0-100 μM) shows FEN-1 and DNase I activity with IC50s of >100, >100 μM, respectively.ERCC1-XPF-IN-2 slow binding kinetics with an Kd value of ~30 μM.ERCC1-XPF-IN-2 shows not toxic to Hep-G2 cells at 10 μM and relatively short mouse and human microsomal half-lives with t1/2 value of 23 min and 28 min for mouse and human, respectively.ERCC1-XPF-IN-2 (0-60 μM; 24 h) shows inhibition of nucleotide excision repair (NER) with an IC50 value of 15.6 μM in A375 cells.ERCC1-XPF-IN-2 (0-60 μM) increases the cisplatin activity with no toxicity.ERCC1-XPF-IN-2 (10 μM; 6h) causes a delay in DNA repair by a right shift towards higher numbers of γH2AX foci per cell.
ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC50 value of 0.6 μM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays.
体外研究：
ERCC1-XPF-IN-2 (compound 13) (0-100 μM) shows FEN-1 and DNase I activity with IC50s of >100, >100 μM, respectively.ERCC1-XPF-IN-2 slow binding kinetics with an Kd value of ~30 μM.ERCC1-XPF-IN-2 shows not toxic to Hep-G2 cells at 10 μM and relatively short mouse and human microsomal half-lives with t1/2 value of 23 min and 28 min for mouse and human, respectively.ERCC1-XPF-IN-2 (0-60 μM; 24 h) shows inhibition of nucleotide excision repair (NER) with an IC50 value of 15.6 μM in A375 cells.ERCC1-XPF-IN-2 (0-60 μM) increases the cisplatin activity with no toxicity.ERCC1-XPF-IN-2 (10 μM; 6h) causes a delay in DNA repair by a right shift towards higher numbers of γH2AX foci per cell.
产品资料
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