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编 号：F741272
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1mg
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5mg
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CAS No: 1791416-49-3
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生物活性：
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism.
体内研究：
Elezanumab (ABT-555; AE12-1Y-QL; 1-10 mg/kg; 静脉给药; 每周一次; 共 5 剂) 在视神经挤压和视神经炎雌性 Lewis 大鼠模型中促进轴突再生并防止视网膜神经纤维层退化。 Elezanumab (0.01, 0.1, 1, 10 mg/kg; 静脉给药; 每周一次; 共 3 剂) 在脊柱靶向实验性自身免疫性脑脊髓炎 (EAE) 雌性 Lewis 大鼠模型中促进轴突再生和髓鞘再生，减少炎症病变面积并改善功能恢复。 Animal Model:Female Lewis rat optic neuritis models
Dosage:1, 3, or 10 mg/kg
Administration:IV; once a week for 5 doses
Result:Protected against the optic nerve inflammationinduced RNFL degeneration.Showed significant protection of the RNFL, as demonstrated by decreased reduction in RNFL thickness measured by optical coherence tomography (OCT) with 10 mg/kg
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism.
体内研究：
Elezanumab (ABT-555; AE12-1Y-QL; 1-10 mg/kg; 静脉给药; 每周一次; 共 5 剂) 在视神经挤压和视神经炎雌性 Lewis 大鼠模型中促进轴突再生并防止视网膜神经纤维层退化。 Elezanumab (0.01, 0.1, 1, 10 mg/kg; 静脉给药; 每周一次; 共 3 剂) 在脊柱靶向实验性自身免疫性脑脊髓炎 (EAE) 雌性 Lewis 大鼠模型中促进轴突再生和髓鞘再生，减少炎症病变面积并改善功能恢复。 Animal Model:Female Lewis rat optic neuritis models
Dosage:1, 3, or 10 mg/kg
Administration:IV; once a week for 5 doses
Result:Protected against the optic nerve inflammationinduced RNFL degeneration.Showed significant protection of the RNFL, as demonstrated by decreased reduction in RNFL thickness measured by optical coherence tomography (OCT) with 10 mg/kg
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