产品
编 号：F741266
分子式：C32H32FN5O4
分子量：569.63
分子式：C32H32FN5O4
分子量：569.63
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
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询价
结构图
CAS No: 1693734-80-3
产品详情
生物活性：
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has?the?potential?for?cancer research.
体内研究：
NXP800 (35 mg/kg；口服；每天一次，持续 20 天) 抑制皮下生长的已建立的 SK-OV-3 人卵巢癌实体瘤异种移植物，相对于对照，肿瘤生长抑制 (TGI) 为 120%。药代动力学分析SpeciesRouteDose (mg/kg)Tmax (h)AUClast (ng·h/mL)Cltb (mL/min/kg)t1/2 (h)F (%)AUCu0-t (h·nM)Free Cav0-24h (nM)Clu (mL/min/kg)
mousepo/iv5/52.06000 (7800-4600) (po)10 (10-9.7) (iv)4.042 (po)723.3830 (iv)
ratpo/iv5/16.02600 (po)24 (iv)3.145 (po)863.7730 (iv)
dogpo/iv2.5/0.52.0250 (po)21 (iv)1.49.1 (po)351.9150 (iv)
体外研究：
NXP800 (example 169) inhibits U20S cells viability (IC50=0.056 μM).
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has?the?potential?for?cancer research.
体内研究：
NXP800 (35 mg/kg；口服；每天一次，持续 20 天) 抑制皮下生长的已建立的 SK-OV-3 人卵巢癌实体瘤异种移植物，相对于对照，肿瘤生长抑制 (TGI) 为 120%。药代动力学分析SpeciesRouteDose (mg/kg)Tmax (h)AUClast (ng·h/mL)Cltb (mL/min/kg)t1/2 (h)F (%)AUCu0-t (h·nM)Free Cav0-24h (nM)Clu (mL/min/kg)
mousepo/iv5/52.06000 (7800-4600) (po)10 (10-9.7) (iv)4.042 (po)723.3830 (iv)
ratpo/iv5/16.02600 (po)24 (iv)3.145 (po)863.7730 (iv)
dogpo/iv2.5/0.52.0250 (po)21 (iv)1.49.1 (po)351.9150 (iv)
体外研究：
NXP800 (example 169) inhibits U20S cells viability (IC50=0.056 μM).
产品资料
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