产品
编 号:F741263
分子式:C20H16O2S
分子量:320.4
产品类型
结构图
CAS No: 1666119-75-0
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产品详情
生物活性:
hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC50 value and a Ki value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an IC50 value of 33.82 μM. hMAO-B-IN-4 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research.
体外研究:
hMAO-B-IN-4 (0-40 μM) 对 hMAO-B 相比于 hMAO-A 具有高选择性,SI 值为 504.791。hMAO-B-IN-4 (0-40 μM) 抑制 hMAO-A 和 hMAO-B,IC50 值分别为 33.821 和 0.067 μM。