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编 号:F741191
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CAS No: 1407495-02-6
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生物活性:
Bococizumab (PF-04950615) is an anti-human PCSK9 inhibitory antibody that reduces LDL cholesterol levels. Bococizumab can be used in the research of hypercholesterolemia.
体内研究:
Bococizumab (0-100 mg/kg, i.v.) decreases maternal and fetal cholesterol and does not affect rat embryo-fetal development.Animal Model:Pregnant Sprague-Dawley (SD) rats
Dosage:0, 10, 30, and 100 mg/kg
Administration:Intravenous injection (i.v.)
Result:Decreased in fetal cholesterol levels.Showed well tolerance and no effects on ovarian or uterine parameters.