产品
编 号:F741175
分子式:C12H10N2S
分子量:214.29
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5mg
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10mg
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25mg
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生物活性:
SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research.

体内研究:
SKA-111 (1 μM 用于心脏灌注) 改善了 Bradykinin (HY-P0206) 诱导的离体大鼠心脏冠状动脉扩张。Animal Model:Langendorff in rat hearts
Dosage:1 μM
Administration:Cardiac perfusion
Result:Potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.

体外研究:
SKA-111 (1 μM,5 分钟) 在猪内皮细胞中引起 KCa3.1 膜超极化。SKA-111 (1 μM, 5 分钟) 在猪大冠状动脉 (PCA) 中诱导显著增强 Bradykinin 诱导的内皮衍生超极化 (EDH) 型舒张。
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