产品
编 号：F741173
分子式：C19H23N3O3S
分子量：373.47
分子式：C19H23N3O3S
分子量：373.47
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1358751-06-0
产品详情
生物活性：
Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders.
体内研究：
Osavampator (0.03-0.3 mg/kg, p.o., single dose) 增强正常大鼠的视觉学习记忆能力。Osavampator (0.3 mg/kg, p.o., single dose) 增强表现差的大鼠的持续注意力。Osavampator (0.06 mg/kg, p.o., single dose) 可改善猴的工作记忆。Osavampator (1 mg/kg, p.o., single dose) 对 RSBM (降低顺从行为模型) 大鼠产生抗抑郁样作用。Animal Model:Normal rats
Dosage:0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg
Administration:Oral gavage (p.o.)
Result:Improved the novelty discrimination index (NDI).
Animal Model:Poor performing rats
Dosage:0.3 mg/kg
Administration:Oral gavage (p.o.)
Result:Increased correct responses and decreased omissions in the poor performing rats.
Animal Model:Fasted monkey
Dosage:0.06 mg/kg
Administration:Oral gavage (p.o.)
Result:Significantly increased delayed match-to-sample (DMTS) accuracy at a 16-s delay interval.Maintained the beneficial effect 24 h after administration.
Animal Model:submissive behavior model
Dosage:0.1 mg/kg, 1 mg/kg
Administration:Oral gavage (p.o.)
Result:Led to a significant reduction in dominance levels compared with vehicle treatment starting from the seventh day of treatment and maintained throughout the study period. Had a significant effect in reducing dominance levels at 0.1 and 1 mg/kg.
Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders.
体内研究：
Osavampator (0.03-0.3 mg/kg, p.o., single dose) 增强正常大鼠的视觉学习记忆能力。Osavampator (0.3 mg/kg, p.o., single dose) 增强表现差的大鼠的持续注意力。Osavampator (0.06 mg/kg, p.o., single dose) 可改善猴的工作记忆。Osavampator (1 mg/kg, p.o., single dose) 对 RSBM (降低顺从行为模型) 大鼠产生抗抑郁样作用。Animal Model:Normal rats
Dosage:0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg
Administration:Oral gavage (p.o.)
Result:Improved the novelty discrimination index (NDI).
Animal Model:Poor performing rats
Dosage:0.3 mg/kg
Administration:Oral gavage (p.o.)
Result:Increased correct responses and decreased omissions in the poor performing rats.
Animal Model:Fasted monkey
Dosage:0.06 mg/kg
Administration:Oral gavage (p.o.)
Result:Significantly increased delayed match-to-sample (DMTS) accuracy at a 16-s delay interval.Maintained the beneficial effect 24 h after administration.
Animal Model:submissive behavior model
Dosage:0.1 mg/kg, 1 mg/kg
Administration:Oral gavage (p.o.)
Result:Led to a significant reduction in dominance levels compared with vehicle treatment starting from the seventh day of treatment and maintained throughout the study period. Had a significant effect in reducing dominance levels at 0.1 and 1 mg/kg.
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