产品
编 号：F741142
分子式：C23H17Cl2NO4
分子量：442.29
分子式：C23H17Cl2NO4
分子量：442.29
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CAS No: 1246964-32-8
产品详情
生物活性：
CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
体内研究：
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model.CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue.Animal Model:Male athymic nu/nu mice (4 weeks old) are injected H441 cells
Dosage:0.2, 0.4 mg/kg
Administration: I.p. daily for 4 weeks
Result:Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.
体外研究：
CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity.CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively.CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells.CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells.CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.
CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
体内研究：
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model.CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue.Animal Model:Male athymic nu/nu mice (4 weeks old) are injected H441 cells
Dosage:0.2, 0.4 mg/kg
Administration: I.p. daily for 4 weeks
Result:Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.
体外研究：
CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity.CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively.CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells.CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells.CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.
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