产品
编 号：F741140
分子式：C19H19F3N2O2
分子量：364.36
分子式：C19H19F3N2O2
分子量：364.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1241280-25-0
产品详情
生物活性：
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
体内研究：
SAE-14 (compound SAE-14) (i.th.; 2.9 μM; once) can reverse nerve injury-induced allodynia in mice.Animal Model:Male and female ICR mice
Dosage:2.9 μM
Administration:intrathecal (i.th.) injections; 2.9 μM; once
Result:Reversed CCI-induced mechanical allodynia in a time-dependent manner.
体外研究：
SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC50 value below 50 nM.
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
体内研究：
SAE-14 (compound SAE-14) (i.th.; 2.9 μM; once) can reverse nerve injury-induced allodynia in mice.Animal Model:Male and female ICR mice
Dosage:2.9 μM
Administration:intrathecal (i.th.) injections; 2.9 μM; once
Result:Reversed CCI-induced mechanical allodynia in a time-dependent manner.
体外研究：
SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC50 value below 50 nM.
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