产品
编 号：F741136
分子式：C21H16N4O3S2
分子量：436.51
分子式：C21H16N4O3S2
分子量：436.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1235032-75-3
产品详情
生物活性：
Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL).
体内研究：
Assessment of Pharmacokinetics (PK) profile of Bcl-xL antagonist 2 (compound 14) in rat.iv (1 mg/kg)po (5 mg/kg)
CLp (mL/min/kg)Vss (L/kg)t 1/2 (h)F %
0.470.166.016
Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL).
体内研究：
Assessment of Pharmacokinetics (PK) profile of Bcl-xL antagonist 2 (compound 14) in rat.iv (1 mg/kg)po (5 mg/kg)
CLp (mL/min/kg)Vss (L/kg)t 1/2 (h)F %
0.470.166.016
产品资料
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