产品
编 号：F741067
分子式：C15H16N2O5S
分子量：336.36
分子式：C15H16N2O5S
分子量：336.36
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
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10mg
询价
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25mg
询价
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50mg
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结构图
CAS No: 939228-52-1
产品详情
生物活性：
CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells.
体外研究：
CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia.Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2.Resistance to CCI-007 can occur by upregulation of MLL target gene expression.
CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells.
体外研究：
CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia.Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2.Resistance to CCI-007 can occur by upregulation of MLL target gene expression.
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