产品
编 号：F741066
分子式：C17H15FO4
分子量：302.3
分子式：C17H15FO4
分子量：302.3
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 937820-89-8
产品详情
生物活性：
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1.
体内研究：
JC2-11 (250 μg/鼠；腹腔注射；单剂量) 显著抑制了 C57BL/6 小鼠模型中非典型 (NC) 炎症小体中 caspase-1 (p20) 和 IL-1β 的释放，弱化了 NC 炎症小体的激活。Animal Model:C57BL/6 mice (8 weeks, female).
Dosage:250 μg/mouse.
Administration:Intraperitoneal injection; single dose.
Result:Exhibited inhibitory effect on NC inflammatory body.
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1.
体内研究：
JC2-11 (250 μg/鼠；腹腔注射；单剂量) 显著抑制了 C57BL/6 小鼠模型中非典型 (NC) 炎症小体中 caspase-1 (p20) 和 IL-1β 的释放，弱化了 NC 炎症小体的激活。Animal Model:C57BL/6 mice (8 weeks, female).
Dosage:250 μg/mouse.
Administration:Intraperitoneal injection; single dose.
Result:Exhibited inhibitory effect on NC inflammatory body.
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