产品
编 号：F069868
分子式：C17H26ClNO
分子量：295.85
分子式：C17H26ClNO
分子量：295.85
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 120447-62-3
产品详情
生物活性：
(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively.
体内研究：
(±)- Vesamicol hydrochloride (3 mg/kg；腹膜内注射；一次；雄性 Wistar 大鼠) 处理增加大脑所有区域的胞质乙酰胆碱 (ACh) 水平，而除纹状体外的所有区域的囊泡 ACh 水平均降低。Animal Model:Male Wistar rats (120-300 g)
Dosage:3 mg/kg
Administration:Intraperitoneal injection; once
Result:The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.
体外研究：
(±)- Vesamicol hydrochloride 的药理作用归因于抑制乙酰胆碱转运到突触小泡和随后乙酰胆碱的量子释放。
(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively.
体内研究：
(±)- Vesamicol hydrochloride (3 mg/kg；腹膜内注射；一次；雄性 Wistar 大鼠) 处理增加大脑所有区域的胞质乙酰胆碱 (ACh) 水平，而除纹状体外的所有区域的囊泡 ACh 水平均降低。Animal Model:Male Wistar rats (120-300 g)
Dosage:3 mg/kg
Administration:Intraperitoneal injection; once
Result:The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.
体外研究：
(±)- Vesamicol hydrochloride 的药理作用归因于抑制乙酰胆碱转运到突触小泡和随后乙酰胆碱的量子释放。
产品资料
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