产品
编 号：F741026
分子式：C14H10N4O
分子量：250.26
分子式：C14H10N4O
分子量：250.26
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 878581-60-3
产品详情
生物活性：
QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer.
体内研究：
QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts.Animal Model:NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)
Dosage:10 and 20 mg/kg
Administration:Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg)
Result:Delayed growth of the tumors, and no systemic toxicity.
体外研究：
QN523 (72 h) has cytotoxicity with IC50 values ranging from 0.1 to 5.7 μM across 12 cell lines.QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells.
QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer.
体内研究：
QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts.Animal Model:NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)
Dosage:10 and 20 mg/kg
Administration:Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg)
Result:Delayed growth of the tumors, and no systemic toxicity.
体外研究：
QN523 (72 h) has cytotoxicity with IC50 values ranging from 0.1 to 5.7 μM across 12 cell lines.QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells.
产品资料
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