产品
编 号：F741000
分子式：C16H31NO2
分子量：269.42
分子式：C16H31NO2
分子量：269.42
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 849461-90-1
产品详情
生物活性：
nAChR-IN-1 (2,2,6,6-Tetramethylpiperidin-4-yl heptanoate) is a tetramethylpiperidine heptanoate, a selective nicotinic acetylcholine receptor (nAChR) inhibitor that inhibits nAChRs lacking α5, α6, or β3 subunits. nAChR-IN-1 has the effect of preventing nerve disorder, can be used for nicotinic acetylcholine receptor dysfunction or neurological disorders research.
体内研究：
nAChR-IN-1 (20 mg/kg; s.c.; single dose) improves nicotine-induced hypomotility and hypothermia in a time-dependent manner in mice.Animal Model:Nicotine-induced mice model
Dosage:20 mg/kg
Administration:Subcutaneous injection; single dose; 15 minutes prior to the injection of nicotine (1.5 mg/kg)?
Result:Increased locomotor activity in mice, even if nicotine-induced decrease.Showed no effect on body temperature.
Animal Model:Tail-flick and hot-platemodel in mice
Dosage:0, 0.1, 1, 5 mg/kg
Administration:Subcutaneous injection; single dose
Result:Blocked the antinociceptive effect of nicotine in the hot-plate.Time-dependently blocked nicotine-induced antinociception.
体外研究：
nAChR-IN-1 (100 nM) inhibits nAChR with inhibition rate of 90% in Xenovus oocytes, and suppresses AChR subtypes (mouse muscle-type (α1β1εδ) nAChR, three different pairwise combinations of rat neuronal alpha and beta subunits (α3β4, α4β2, and α3β2), and α7 homomeric neuronal nAChR) with IC50s (area) of 390, 1.2, 110, 75, 440, 460, 430, 2.7, 1.0, 1.4, and 18.3 nM, respectively, based on the decrease in the net charge of the ACh response.
nAChR-IN-1 (2,2,6,6-Tetramethylpiperidin-4-yl heptanoate) is a tetramethylpiperidine heptanoate, a selective nicotinic acetylcholine receptor (nAChR) inhibitor that inhibits nAChRs lacking α5, α6, or β3 subunits. nAChR-IN-1 has the effect of preventing nerve disorder, can be used for nicotinic acetylcholine receptor dysfunction or neurological disorders research.
体内研究：
nAChR-IN-1 (20 mg/kg; s.c.; single dose) improves nicotine-induced hypomotility and hypothermia in a time-dependent manner in mice.Animal Model:Nicotine-induced mice model
Dosage:20 mg/kg
Administration:Subcutaneous injection; single dose; 15 minutes prior to the injection of nicotine (1.5 mg/kg)?
Result:Increased locomotor activity in mice, even if nicotine-induced decrease.Showed no effect on body temperature.
Animal Model:Tail-flick and hot-platemodel in mice
Dosage:0, 0.1, 1, 5 mg/kg
Administration:Subcutaneous injection; single dose
Result:Blocked the antinociceptive effect of nicotine in the hot-plate.Time-dependently blocked nicotine-induced antinociception.
体外研究：
nAChR-IN-1 (100 nM) inhibits nAChR with inhibition rate of 90% in Xenovus oocytes, and suppresses AChR subtypes (mouse muscle-type (α1β1εδ) nAChR, three different pairwise combinations of rat neuronal alpha and beta subunits (α3β4, α4β2, and α3β2), and α7 homomeric neuronal nAChR) with IC50s (area) of 390, 1.2, 110, 75, 440, 460, 430, 2.7, 1.0, 1.4, and 18.3 nM, respectively, based on the decrease in the net charge of the ACh response.
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