产品
编 号：F069838
分子式：C32H38N4O6S
分子量：606.73
分子式：C32H38N4O6S
分子量：606.73
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CAS No: 1204416-97-6
产品详情
生物活性：
TMC647055 is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 can be used for the research of Hepatitis C virus (HCV).
体内研究：
TMC647055 (compound 18a) (2 mg/kg, iv.; 10mg/kg, po.) shows an acceptable PK profile, characterized byhigh oral bioavailability and high systemic exposure after single oral dosingof 10 mg/kg, combined with a moderate plasma clearanceand low volume of distribution.Animal Model:Rats
Dosage:2 mg/kg; 10mg/kg
Administration:2 mg/kg, iv.; 10mg/kg, po.; singel
Result: No.Cl (L/h/kg)Cmax(ng/mL)[Liver] (ng/mL)L/PF (%)
TMC647055 (compound 18a)3.2440780046＞66
体外研究：
TMC647055 has antiviral activity with an EC90 value of 0.3 μM in Huh7-Luc cells.TMC647055 has potent combine activity with an EC50 value of 82 nM in cellular HCV assays.
TMC647055 is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 can be used for the research of Hepatitis C virus (HCV).
体内研究：
TMC647055 (compound 18a) (2 mg/kg, iv.; 10mg/kg, po.) shows an acceptable PK profile, characterized byhigh oral bioavailability and high systemic exposure after single oral dosingof 10 mg/kg, combined with a moderate plasma clearanceand low volume of distribution.Animal Model:Rats
Dosage:2 mg/kg; 10mg/kg
Administration:2 mg/kg, iv.; 10mg/kg, po.; singel
Result: No.Cl (L/h/kg)Cmax(ng/mL)[Liver] (ng/mL)L/PF (%)
TMC647055 (compound 18a)3.2440780046＞66
体外研究：
TMC647055 has antiviral activity with an EC90 value of 0.3 μM in Huh7-Luc cells.TMC647055 has potent combine activity with an EC50 value of 82 nM in cellular HCV assays.
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