产品
编 号：F740919
分子式：C28H27NO6
分子量：473.52
分子式：C28H27NO6
分子量：473.52
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 447415-26-1
产品详情
生物活性：
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment. NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
NH3 (46.2-27，700 nmol/kg/天；7 天) 从 46.2 nmol/kg/天开始适度降低心率，但在 >2920 nmol/kg/天时效果消失。NH3 对 46.2 nmol/kg/day T3 的降胆固醇作用无影响，但对 924 nmol/kg/day 剂量下的心动过速和 TSH 抑制作用有抑制作用。
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment. NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
NH3 (46.2-27，700 nmol/kg/天；7 天) 从 46.2 nmol/kg/天开始适度降低心率，但在 >2920 nmol/kg/天时效果消失。NH3 对 46.2 nmol/kg/day T3 的降胆固醇作用无影响，但对 924 nmol/kg/day 剂量下的心动过速和 TSH 抑制作用有抑制作用。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备