产品
编 号：F740901
分子式：C22H16BrN3O4
分子量：466.28
分子式：C22H16BrN3O4
分子量：466.28
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 420826-65-9
产品详情
生物活性：
BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer.
体内研究：
BAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CLb,hmic of 0.47 L/h/kg in human liver microsomes and CLb,rhep of 3.9 L/h/kg in rat liver hepatocytes.Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice.RouteP.O. (100 mg/kg) I.P. S.C.
AUC0-tlast (mg/L·h)0.0740.260.045
Cmax (nM)35594.4
体外研究：
BAY-0069 inhibits CYP2C8 with an IC50 of 4.3 μM.BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9.
BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer.
体内研究：
BAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CLb,hmic of 0.47 L/h/kg in human liver microsomes and CLb,rhep of 3.9 L/h/kg in rat liver hepatocytes.Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice.RouteP.O. (100 mg/kg) I.P. S.C.
AUC0-tlast (mg/L·h)0.0740.260.045
Cmax (nM)35594.4
体外研究：
BAY-0069 inhibits CYP2C8 with an IC50 of 4.3 μM.BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9.
产品资料
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