产品
编 号:F740856
分子式:C13H8Cl2N2O2S
分子量:327.19
产品类型
结构图
CAS No: 326901-92-2
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产品详情
生物活性:
WDR5-IN-6 is a WDR5 inhibitor, targeting to WBM site. WDR5-IN-6 inhibits cell proliferation of neuroblastoma cell lines with potent anti-tumor activity. WDR5-IN-6 shows high synergy with OICR-9429 (HY-16993), a WDR5 inhibitor targeting to WIN site. WDR5-IN-6 can be used for reasearch in neuroblastoma.
体外研究:
WDR5-IN-6 (compound 19) 抑制 IMR32 和 LAN5 细胞的增殖,EC50 值分别为 12.34 和 14.89 μM,对 SK-N-AS 细胞有中等抑制作用,在 20 μM时对 HEK293T 细胞没有影响。