产品
编 号：F740761
分子式：C15H20F3N3O3S
分子量：379.4
分子式：C15H20F3N3O3S
分子量：379.4
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 141283-87-6
产品详情
生物活性：
Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
体内研究：
Fuzapladib (IS-741) (p.o., 50 mg/kg, 7 days) 抑制中性粒细胞浸润炎性病变，对减轻大鼠三硝基苯磺酸 (TNBS) 回肠炎有效。Animal Model:Rats
Dosage:50 mg/kg
Administration:P.o.; for 7 days
Result:Significantly reduced myeloperoxidase (MPO) activity and mucosal IL-8 levels in rat ileum, reduced polymorphonuclear cells and Mac-1 positivity Infiltration of cells into inflammatory lesions, effectively alleviated trinitrobenzenesulfonic acid (TNBS)-induced ileitis.
体外研究：
Fuzapladib (IS-741) (1 μM, 3 h) 在脂多糖刺激下，可显着抑制 HL-60 细胞与 HUVEC 的粘附。
Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
体内研究：
Fuzapladib (IS-741) (p.o., 50 mg/kg, 7 days) 抑制中性粒细胞浸润炎性病变，对减轻大鼠三硝基苯磺酸 (TNBS) 回肠炎有效。Animal Model:Rats
Dosage:50 mg/kg
Administration:P.o.; for 7 days
Result:Significantly reduced myeloperoxidase (MPO) activity and mucosal IL-8 levels in rat ileum, reduced polymorphonuclear cells and Mac-1 positivity Infiltration of cells into inflammatory lesions, effectively alleviated trinitrobenzenesulfonic acid (TNBS)-induced ileitis.
体外研究：
Fuzapladib (IS-741) (1 μM, 3 h) 在脂多糖刺激下，可显着抑制 HL-60 细胞与 HUVEC 的粘附。
产品资料
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