产品
编 号：F069391
分子式：C22H38O5
分子量：382.53
分子式：C22H38O5
分子量：382.53
产品类型
规格
价格
是否有货
结构图
CAS No: 120373-36-6
产品详情
生物活性：
Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.
体内研究：
Unoprostone (0.06%, 0.12%; topical instillation; 3 μl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner.Animal Model:Male mice (6 weeks old)
Dosage:0.06%, 0.12%
Administration:Topical instillation; 3 μl
Result:Reduced mouse IOP in a dose-dependent manner.
体外研究：
Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 h before H2O2 treatment) protects against H2O2-induced cell death in a concentration-dependent manner and the effect is significant at 0.1 μM and 1 μM concentrations. Pretreatment with Unoprostone at concentrations of 0.1 to 3 μM protects against light-induced cell death in a concentration-dependent manner; the effect is significant at the 1 and 3 μM concentrations. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation. Unoprostone has prostaglandin F2α receptors (FP) binding affinity with a Ki of 3.86 μM.
Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.
体内研究：
Unoprostone (0.06%, 0.12%; topical instillation; 3 μl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner.Animal Model:Male mice (6 weeks old)
Dosage:0.06%, 0.12%
Administration:Topical instillation; 3 μl
Result:Reduced mouse IOP in a dose-dependent manner.
体外研究：
Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 h before H2O2 treatment) protects against H2O2-induced cell death in a concentration-dependent manner and the effect is significant at 0.1 μM and 1 μM concentrations. Pretreatment with Unoprostone at concentrations of 0.1 to 3 μM protects against light-induced cell death in a concentration-dependent manner; the effect is significant at the 1 and 3 μM concentrations. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation. Unoprostone has prostaglandin F2α receptors (FP) binding affinity with a Ki of 3.86 μM.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备