产品
编 号:F739685
分子式:C75H139N3O16S4
分子量:1467.18
产品类型
结构图
CAS No: 1857340-78-3
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产品详情
生物活性:
4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model.
体内研究:
4A3-SC8 mediates siRNA accumulation mainly in liver and slightly in the spleen and kidneys 24 hours after intravenous injection at dosage of 1 mg siRNA/kg and enables >95% FVII knockdown in mice. After injection with 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), mice became sick and lost nearly 20% of their weight on the first day postinjection.