产品
编 号：F737850
分子式：C24H23N3O4
分子量：417.46
分子式：C24H23N3O4
分子量：417.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 724737-74-0
产品详情
生物活性：
Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research.
体内研究：
Protein deglycase DJ-1 against-1 (化合物 23；1 mg/kg；腹腔注射；预处理一小时；每天；持续 4 天) 在 DJ-1(+/+) 小鼠中显著恢复MPTP诱导的运动、多巴胺能神经元细胞死亡和多巴胺含量，而在 DJ-1(-/-) 小鼠中没有。Animal Model:Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks
Dosage:1 mg/kg
Administration:IP; pretreatment one hour; daily; for 4 days
Result:Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.
Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research.
体内研究：
Protein deglycase DJ-1 against-1 (化合物 23；1 mg/kg；腹腔注射；预处理一小时；每天；持续 4 天) 在 DJ-1(+/+) 小鼠中显著恢复MPTP诱导的运动、多巴胺能神经元细胞死亡和多巴胺含量，而在 DJ-1(-/-) 小鼠中没有。Animal Model:Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks
Dosage:1 mg/kg
Administration:IP; pretreatment one hour; daily; for 4 days
Result:Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.
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