产品
编 号：F727697
分子式：C10H11FN2O2S
分子量：242.27
分子式：C10H11FN2O2S
分子量：242.27
产品类型
规格
价格
是否有货
1mg
320
In-stock
5mg
840
In-stock
10mg
1360
In-stock
25mg
2960
In-stock
50mg
5200
In-stock
结构图
CAS No: 1204572-55-3
产品详情
生物活性：
BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM).
体外研究：
BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM).
体外研究：
BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
产品资料
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