产品
编 号:F726230
分子式:C13H24N4O3S.1/2H3O
分子量:325.43
产品类型
结构图
CAS No: 91524-16-2
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生物活性:
Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect.
体内研究:
Timolol (hemihydrate) (5 mg/kg daily for 12-week) has a cardioprotective effect via inhibition of ERS response in diabetic rats.Animal Model:Male Wistar rats.
Dosage:5 mg/kg
Administration:Timolol (5 mg/kg daily for 12-week)
Result:Showed cardioprotective effect.
体外研究:
Timolol (hemihydrate) can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol (hemihydrate) can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects.