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编 号:F724495
分子式:C9H17NO5
分子量:219.23
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生物活性:
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice.

体内研究:
(±)-Pantothenic acid (3 × 200 mg/kg; IP, single dosage) blocks VPA-induced decreases in c-Myb and Pim-1 protein expression; reduces the incidence of NTD to 6.8% in VPA-injected CD-1 mice, while incidence of the untreated group is 23.6%.
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