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编 号:F719468
分子式:C12H11NO4
分子量:233.22
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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生物活性:
SEMBL is a potent NF-κB inhibitor. SEMBL can inhibit NF-κB-DNA binding, and also inhibits NF-κB-dependent inflammatory cytokine secretions. SEMBL inhibits cancer cell migration and invasion via decreasing MMP expression. SEMBL can be used for researching anticancer.

体外研究:
SEMBL inhibits MMP-2 expression and cellular metastatic activity in ovarian carcinoma cells.SEMBL inhibits the cell-free DNA binding of NF-κB in the ES-2 nuclear extract and inhibits the constitutively activated NF-κB activity in ovarian carcinoma cells.SEMBL inhibits cellular migration, invasion and MMP-2 expression in ovarian carcinoma cells at non-toxic concentrations.
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