产品
编 号:F719145
分子式:C21H22F3N3O3S
分子量:453.48
产品类型
结构图
CAS No: 901260-40-0
联系客服
产品详情
生物活性:
LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .
体外研究:
LpxH-IN-AZ1 displays IC50 values of 0.36 μM against K. pneumoniae LpxH and 0.14 μM against E. coli LpxH, respectively. LpxH-IN-AZ1 (1 μM) inhibits 75% of the activity of K. pneumoniae LpxH and 83% of the activity of E. coli LpxH in the presence of 100 μM UDPDAGn.