产品
编 号：F718972
分子式：C46H73N13O11S2
分子量：1048.28
分子式：C46H73N13O11S2
分子量：1048.28
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CAS No: 876296-47-8
产品详情
生物活性：
Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock.
体内研究：
Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model.Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis.Animal Model:LPS-induced, fluid-resuscitated rabbit endotoxemia model.
Dosage:1 μg/kg/min
Administration:Left jugular vein infusion for 12 min
Result:Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.
体外研究：
Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction.Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs.Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs.
Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock.
体内研究：
Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model.Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis.Animal Model:LPS-induced, fluid-resuscitated rabbit endotoxemia model.
Dosage:1 μg/kg/min
Administration:Left jugular vein infusion for 12 min
Result:Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.
体外研究：
Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction.Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs.Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs.
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