产品
编 号：F718879
分子式：C21H33N3O4S2
分子量：455.63
分子式：C21H33N3O4S2
分子量：455.63
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规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
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询价
结构图
CAS No: 859525-02-3
产品详情
生物活性：
Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes.
体内研究：
TTP399（200 mg/kg，口服，口服）对禁食大鼠的血浆葡萄糖和胰岛素没有影响。TTP399（75 或 150 mg/kg，每天，持续 4 周）改善 ob/ob 小鼠模型的葡萄糖稳态。TTP399（50 mg/kg，每天，持续 13 周）在小型猪模型的口服葡萄糖耐量试验 (OGTT) 期间有效降低血浆葡萄糖 。Animal Model:Nondiabetic fasted rats
Dosage:200 mg/kg
Administration:200 mg/kg, per os (p.o.)
Result:Did not change the insulin and glucose concentrations in plasma.
Animal Model:ob/ob mouse model
Dosage:75 or 150 mg/kg
Administration:75 or 150 mg/kg, per day, for 4 weeks
Result:Reduced the expression of HbA1c, blood glucose concentrations, lactate concentrations and liver glycogen depots.Improved the lipid profile, reduced plasma, liver TG concentrations and the weight gain at the highest dose.
Animal Model:Gottingen minipigs
Dosage:50 mg/kg
Administration:50 mg/kg, per day, for 13 weeks
Result:Eliminated the blood glucose excursion in Minipigs.
体外研究：
Cadisegliatin (TTP-399) 增加大鼠肝细胞的葡萄糖代谢，15 nM 葡萄糖中乳酸和糖原的 EC50 值分别为 2.39 μM 和 2.64 μM .
Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes.
体内研究：
TTP399（200 mg/kg，口服，口服）对禁食大鼠的血浆葡萄糖和胰岛素没有影响。TTP399（75 或 150 mg/kg，每天，持续 4 周）改善 ob/ob 小鼠模型的葡萄糖稳态。TTP399（50 mg/kg，每天，持续 13 周）在小型猪模型的口服葡萄糖耐量试验 (OGTT) 期间有效降低血浆葡萄糖 。Animal Model:Nondiabetic fasted rats
Dosage:200 mg/kg
Administration:200 mg/kg, per os (p.o.)
Result:Did not change the insulin and glucose concentrations in plasma.
Animal Model:ob/ob mouse model
Dosage:75 or 150 mg/kg
Administration:75 or 150 mg/kg, per day, for 4 weeks
Result:Reduced the expression of HbA1c, blood glucose concentrations, lactate concentrations and liver glycogen depots.Improved the lipid profile, reduced plasma, liver TG concentrations and the weight gain at the highest dose.
Animal Model:Gottingen minipigs
Dosage:50 mg/kg
Administration:50 mg/kg, per day, for 13 weeks
Result:Eliminated the blood glucose excursion in Minipigs.
体外研究：
Cadisegliatin (TTP-399) 增加大鼠肝细胞的葡萄糖代谢，15 nM 葡萄糖中乳酸和糖原的 EC50 值分别为 2.39 μM 和 2.64 μM .
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