产品
编 号：F718594
分子式：C32H38F2N2O5S2
分子量：632.78
分子式：C32H38F2N2O5S2
分子量：632.78
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
9000
In-stock
1mg
3180
In-stock
5mg
6880
In-stock
10mg
9640
In-stock
结构图
CAS No: 780750-65-4
产品详情
生物活性：
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis.
体内研究：
In vivo pharmaeokineties data for AZD-5672 (compound 1)SpeciesCIa(mL/min/kg)Vssa (L/kg)t1/2a (h)Fb (%)
Rat285.32.638
Dog185.73.986
a AZD-5672 dosed 1-2 mg/kg i.v. b AZD-5672 dosed 2-5 mg/kg p.o.
体外研究：
AZD-5672 (0, 0.1, 0.3, 1, 3, 10, 30, and 100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner (mean apparent IC50: 32 μM) in Caco-2 cells.
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis.
体内研究：
In vivo pharmaeokineties data for AZD-5672 (compound 1)SpeciesCIa(mL/min/kg)Vssa (L/kg)t1/2a (h)Fb (%)
Rat285.32.638
Dog185.73.986
a AZD-5672 dosed 1-2 mg/kg i.v. b AZD-5672 dosed 2-5 mg/kg p.o.
体外研究：
AZD-5672 (0, 0.1, 0.3, 1, 3, 10, 30, and 100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner (mean apparent IC50: 32 μM) in Caco-2 cells.
产品资料
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