产品
编 号：F718339
分子式：C36H54N12O9
分子量：798.89
分子式：C36H54N12O9
分子量：798.89
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 725715-18-4
产品详情
生物活性：
Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases.
体内研究：
Alirinetide (GM604) (0-20 mg/kg; i.v.; twice daily for 5 days) improves behavioral, biochemical, and histological features in the 6-OHDA mouse model.Animal Model:C57BL/6 mice, 6-hydroxydopamine (6-OHDA) mouse model
Dosage:0, 1, 5, 10 or 20 mg/kg
Administration:Intravenous injection, twice daily for 5 days
Result:Almost completely abrogated 6-OHDA effects at the highest dose, leading to improved motor performance, increased numbers of TH-positive neurons in the substantia nigra, and increased brain levels of dopamine, 3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).
体外研究：
Alirinetide (GM604) (0.1-10 mg/mL; 24 h) prevents SH-SY5Y cell death.Alirinetide (48 h) predominantly represses Parkinson’s disease-associated genes in SH-SY5Y cells, these genes were largely associated with the mitochondrial protein complex and respiratory chain.
Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases.
体内研究：
Alirinetide (GM604) (0-20 mg/kg; i.v.; twice daily for 5 days) improves behavioral, biochemical, and histological features in the 6-OHDA mouse model.Animal Model:C57BL/6 mice, 6-hydroxydopamine (6-OHDA) mouse model
Dosage:0, 1, 5, 10 or 20 mg/kg
Administration:Intravenous injection, twice daily for 5 days
Result:Almost completely abrogated 6-OHDA effects at the highest dose, leading to improved motor performance, increased numbers of TH-positive neurons in the substantia nigra, and increased brain levels of dopamine, 3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).
体外研究：
Alirinetide (GM604) (0.1-10 mg/mL; 24 h) prevents SH-SY5Y cell death.Alirinetide (48 h) predominantly represses Parkinson’s disease-associated genes in SH-SY5Y cells, these genes were largely associated with the mitochondrial protein complex and respiratory chain.
产品资料
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