产品
编 号：F715765
分子式：C18H15F3N4O3S
分子量：424.4
分子式：C18H15F3N4O3S
分子量：424.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 301177-36-6
产品详情
生物活性：
RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment.
体外研究：
RH01386 (270 nM-70 μM; 72hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM.RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells.
RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment.
体外研究：
RH01386 (270 nM-70 μM; 72hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM.RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备