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编 号:F715458
分子式:C16H13Cl2N3O
分子量:334.2
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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生物活性:
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.

体外研究:
Bobcat339 hydrochloride (10 μM; 24 hours) 通过抑制 HT-22 细胞中的 TET 酶功能显著降低 5hmC 水平。
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