产品
编 号：F715436
分子式：C42H46N8O6
分子量：758.86
分子式：C42H46N8O6
分子量：758.86
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CAS No: 2412923-79-4
产品详情
生物活性：
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.
体外研究：
Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined.
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.
体外研究：
Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined.
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