产品
编 号：F715424
分子式：C17H15N3O3
分子量：309.32
分子式：C17H15N3O3
分子量：309.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2404756-81-4
产品详情
生物活性：
X5050 is a REST inhibitor, with an EC50 of 2.1 μM.
体内研究：
X5050 (2 x 2μl of 20 mM) is active in HD pathological context.Animal Model:12-week-old male C57Bl6 mice.2
Dosage:2 x 2μl of 20 mM in 10% DMSO in water.
Administration:Intraventricular injection.
Result:Increased BDNF expression.A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.
体外研究：
X5050 (100 μM, 1 day) induces a dosedependent decrease in the REST isoform in protein level.
X5050 is a REST inhibitor, with an EC50 of 2.1 μM.
体内研究：
X5050 (2 x 2μl of 20 mM) is active in HD pathological context.Animal Model:12-week-old male C57Bl6 mice.2
Dosage:2 x 2μl of 20 mM in 10% DMSO in water.
Administration:Intraventricular injection.
Result:Increased BDNF expression.A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.
体外研究：
X5050 (100 μM, 1 day) induces a dosedependent decrease in the REST isoform in protein level.
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