产品
编 号：F715384
分子式：C22H27F2N3O
分子量：387.47
分子式：C22H27F2N3O
分子量：387.47
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CAS No: 2368253-58-9
产品详情
生物活性：
CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively.
体内研究：
CWHM-1552 (Compound (-)-32a) (orally; 3-30 mg/kg/day for 4 days) inhibits parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day. CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice. CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day, respectively. Animal Model:P. chabaudi ASS infected Mice
Dosage:3, 10, 30 mg/kg
Administration:Orally; daily for 4 days
Result:Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.
Animal Model:Male KM mice
Dosage:2 mg/kg
Administration:I.v. administration; daily
Result:Had respectable half-lives (2.7 h) and low clearance in mice.
CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively.
体内研究：
CWHM-1552 (Compound (-)-32a) (orally; 3-30 mg/kg/day for 4 days) inhibits parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day. CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice. CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day, respectively. Animal Model:P. chabaudi ASS infected Mice
Dosage:3, 10, 30 mg/kg
Administration:Orally; daily for 4 days
Result:Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.
Animal Model:Male KM mice
Dosage:2 mg/kg
Administration:I.v. administration; daily
Result:Had respectable half-lives (2.7 h) and low clearance in mice.
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