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编 号:F715327
分子式:C24H22N6O2
分子量:426.47
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生物活性:
Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM.

体外研究:
Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC50: 2.74 μM), HeLa (IC50: 2.61 μM), HCT116 (IC50: 2.34 μM), NIH: OVCAR-3 (IC50: 2.35 μM) cells compared to the non-cancerous cells like HEK293 (IC50: 8.34 μM) .
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