产品
编 号：F715258
分子式：C25H23N5O3
分子量：441.48
分子式：C25H23N5O3
分子量：441.48
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2241732-30-7
产品详情
生物活性：
BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment.
体内研究：
BTK inhibitor 10 (oral gavage; 30 mg/kg; 21 days; once daily) has a significant improvement in arthritis symptoms in CIA mice. The damage of each of the 4 paws in mice is divided into 0-4 to calculate the total score of the limbs. After 21 days’ oral treatment, BTK030 reduces the arthritic score to 3.62 while the control group shows a value of 8.33.Animal Model:DBA/1J mice injected with collagen as a CIA model
Dosage:30 mg/kg
Administration:oral gavage; 21 days; once daily
Result:Decreased arthritis scores significantly when it compares to control group.
BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment.
体内研究：
BTK inhibitor 10 (oral gavage; 30 mg/kg; 21 days; once daily) has a significant improvement in arthritis symptoms in CIA mice. The damage of each of the 4 paws in mice is divided into 0-4 to calculate the total score of the limbs. After 21 days’ oral treatment, BTK030 reduces the arthritic score to 3.62 while the control group shows a value of 8.33.Animal Model:DBA/1J mice injected with collagen as a CIA model
Dosage:30 mg/kg
Administration:oral gavage; 21 days; once daily
Result:Decreased arthritis scores significantly when it compares to control group.
产品资料
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