产品
编 号：F715254
分子式：C34H33FN6O5
分子量：624.66
分子式：C34H33FN6O5
分子量：624.66
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 2241014-82-2
产品详情
生物活性：
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
体内研究：
ADC-4 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells.Animal Model:Female scid-beige (SCID bg) mice
Dosage:20 mg/kg
Administration:A single intravenous injection (i.v.) for 28 days
Result:Significantly inhibited the growth of tumor in mice.
体外研究：
ADC-4 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of NAMPT inhibitor-linker 2 相关抗体:Cell Proliferation AssayCell Line:GIST-T1 cells
Concentration:0.1 pM-10 nM
Incubation Time:144 hours
Result:Inhibited the cell proliferation of GIST-T1 cells at 0.01-10 nM, and the inhibition remained unchanged after 1 nM.
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
体内研究：
ADC-4 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells.Animal Model:Female scid-beige (SCID bg) mice
Dosage:20 mg/kg
Administration:A single intravenous injection (i.v.) for 28 days
Result:Significantly inhibited the growth of tumor in mice.
体外研究：
ADC-4 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of NAMPT inhibitor-linker 2 相关抗体:Cell Proliferation AssayCell Line:GIST-T1 cells
Concentration:0.1 pM-10 nM
Incubation Time:144 hours
Result:Inhibited the cell proliferation of GIST-T1 cells at 0.01-10 nM, and the inhibition remained unchanged after 1 nM.
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