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编 号：F715110
分子式：C29H38BFO7
分子量：528.42
分子式：C29H38BFO7
分子量：528.42
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CAS No: 2130750-59-1
产品详情
生物活性：
AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines.
体内研究：
AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively.Animal Model:CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae.
Dosage:25 mg/kg.
Administration:Orally, BID for 7 or 14 days.
Result:Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively.
AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines.
体内研究：
AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively.Animal Model:CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae.
Dosage:25 mg/kg.
Administration:Orally, BID for 7 or 14 days.
Result:Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively.
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