产品
编 号：F715046
分子式：C26H37ClN6O2
分子量：501.06
分子式：C26H37ClN6O2
分子量：501.06
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CAS No: 2095432-39-4
产品详情
生物活性：
MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells.
体外研究：
MRT67307 inhibits IKK? and TBK1 with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, but did not inhibit IKKα or IKKβ even at 10 μM. MRT67307 (2 μM) prevents the phosphorylation of IRF3 in bone-marrow-derived macrophages (BMDMs). MRT67307 (2 μM) dose not suppresse the activation of JNK or p38 MAPK by poly(I:C).MRT67307 (1 nM-10 μM) prevents the production of IFNβ in macrophages.MRT67307 (10 μM) is sufficient to reduce phospho-ATG13 to control levels.MRT67307 (10 μM) blocks autophagy in mouse embryonic fibroblasts (MEFs).MRT67307 (5 μM; 4 h) abrogates TBK1/IKKε-induced CYLD phosphorylation in 293T cells.
MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells.
体外研究：
MRT67307 inhibits IKK? and TBK1 with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, but did not inhibit IKKα or IKKβ even at 10 μM. MRT67307 (2 μM) prevents the phosphorylation of IRF3 in bone-marrow-derived macrophages (BMDMs). MRT67307 (2 μM) dose not suppresse the activation of JNK or p38 MAPK by poly(I:C).MRT67307 (1 nM-10 μM) prevents the production of IFNβ in macrophages.MRT67307 (10 μM) is sufficient to reduce phospho-ATG13 to control levels.MRT67307 (10 μM) blocks autophagy in mouse embryonic fibroblasts (MEFs).MRT67307 (5 μM; 4 h) abrogates TBK1/IKKε-induced CYLD phosphorylation in 293T cells.
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