产品
编 号：F068484
分子式：C16H18ClNO6S2
分子量：419.9
分子式：C16H18ClNO6S2
分子量：419.9
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
500mg
1024
In-stock
结构图
CAS No: 120202-66-6
产品详情
生物活性：
Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.
体内研究：
与媒介物相比，Clopidogrel hydrogen sulfate (5 mg/kg) 显著抑制血栓形成。乙酰水杨酸 (0.15 mg/kg) 可以增加氯吡格雷在小鼠体内的抗血栓形成作用；乙酰水杨酸 (0.6 mg/kg) 会减弱氯吡格雷的抗血栓形成作用。Animal Model:Age-matched C57BL/6J male mice weighing at least 25 g were used at 8 to 12 weeks of age
Dosage:5 mg/kg
Administration:Gavage treatment
Result:Clopidogrel significantly inhibited thrombus formation compared with vehicle.When Clopidogrel was given in combination with 0.6 mg/kg ASA, thrombi were significantly larger than those measured with Clopidogrel alone. In contrast, when Clopidogrel was given in combination with 0.15 mg/kg ASA , thrombi were significantly smaller than those in mice treated with Clopidogrel and 0.6 mg/kg ASA, and smaller than those in mice given Clopidogrel alone.
体外研究：
Clopidogrel hydrogen sulfate (1.5 mM；12 和 24 小时) 以浓度和时间依赖性方式上调 TRIB3 和 CHOP 的表达，如通过实时 PCR 和蛋白质印迹分析所测量。 Clopidogrel (1.5 mM；24 hours) 显著诱导人胃上皮细胞 (GES-1) 凋亡。
Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.
体内研究：
与媒介物相比，Clopidogrel hydrogen sulfate (5 mg/kg) 显著抑制血栓形成。乙酰水杨酸 (0.15 mg/kg) 可以增加氯吡格雷在小鼠体内的抗血栓形成作用；乙酰水杨酸 (0.6 mg/kg) 会减弱氯吡格雷的抗血栓形成作用。Animal Model:Age-matched C57BL/6J male mice weighing at least 25 g were used at 8 to 12 weeks of age
Dosage:5 mg/kg
Administration:Gavage treatment
Result:Clopidogrel significantly inhibited thrombus formation compared with vehicle.When Clopidogrel was given in combination with 0.6 mg/kg ASA, thrombi were significantly larger than those measured with Clopidogrel alone. In contrast, when Clopidogrel was given in combination with 0.15 mg/kg ASA , thrombi were significantly smaller than those in mice treated with Clopidogrel and 0.6 mg/kg ASA, and smaller than those in mice given Clopidogrel alone.
体外研究：
Clopidogrel hydrogen sulfate (1.5 mM；12 和 24 小时) 以浓度和时间依赖性方式上调 TRIB3 和 CHOP 的表达，如通过实时 PCR 和蛋白质印迹分析所测量。 Clopidogrel (1.5 mM；24 hours) 显著诱导人胃上皮细胞 (GES-1) 凋亡。
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