产品
编 号：F714963
分子式：C13H8N4
分子量：220.23
分子式：C13H8N4
分子量：220.23
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 2009343-14-8
产品详情
生物活性：
PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an “Arg367-out” pocket.
体内研究：
PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95. Animal Model:Male C57BL6 mice
Dosage:3 mg/kg (p.o.) or 0.5 mg/kg (i.v.) (Pharmacokinetic Analysis)
Administration:PO or IV
Result:Had a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95.
PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an “Arg367-out” pocket.
体内研究：
PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95. Animal Model:Male C57BL6 mice
Dosage:3 mg/kg (p.o.) or 0.5 mg/kg (i.v.) (Pharmacokinetic Analysis)
Administration:PO or IV
Result:Had a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95.
产品资料
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