产品
编 号：F714221
分子式：C22H25FN2O4S
分子量：432.51
分子式：C22H25FN2O4S
分子量：432.51
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1978371-23-1
产品详情
生物活性：
P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion.
体内研究：
P-CAB agent 2 (example 1) 抑制组胺 (histamine (HY-B1204)) 诱导的 SD 大鼠胃酸分泌.P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) 无急性毒性，600mg/kg 对 SD 大鼠动物体重无显着影响。Animal Model:180-220 g, SPF grade, male SD rats
Dosage:2 mg/kg
Administration:P.o.; once
Result:Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.
体外研究：
P-CAB agent 2 (100 μM) 抑制 hERG 钾通道，抑制率为 86.21%，IC50 值为 18.69 M。
P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion.
体内研究：
P-CAB agent 2 (example 1) 抑制组胺 (histamine (HY-B1204)) 诱导的 SD 大鼠胃酸分泌.P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) 无急性毒性，600mg/kg 对 SD 大鼠动物体重无显着影响。Animal Model:180-220 g, SPF grade, male SD rats
Dosage:2 mg/kg
Administration:P.o.; once
Result:Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.
体外研究：
P-CAB agent 2 (100 μM) 抑制 hERG 钾通道，抑制率为 86.21%，IC50 值为 18.69 M。
产品资料
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