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编 号：F712230
分子量：5667.5
分子量：5667.5
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CAS No: 190977-41-4
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生物活性：
Oblimersen is a BCL-2 inhibitor targeting BCL-2 RNA. Oblimersen specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen can be used for cancer research.
体内研究：
Oblimersen (10 mg/kg; i.p.; daily, for 6 days; nude mice bearing H69 xenografts) decreases tumoural vascularisation in vivo.Oblimersen (5-10 mg/kg; i.p.; daily (Monday to Friday), for 3 weeks) has antitumor efficacy in the subcutaneous tumor model.Animal Model:Male severe combined immunodeficient (SCID)-RAG2 mice
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; daily (Monday to Friday), for 3 weeks
Result:Inhibited tumor growth in a dose-dependent manner.
体外研究：
Oblimersen (500 nM; 72 hours; human small-cell lung cancer cell lines H69) decreases BCL-2 protein expression in vitro.Oblimersen (500 nM; 72 hours; human small-cell lung cancer cell lines H69) increases radiation-induced apoptosis.
Oblimersen is a BCL-2 inhibitor targeting BCL-2 RNA. Oblimersen specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen can be used for cancer research.
体内研究：
Oblimersen (10 mg/kg; i.p.; daily, for 6 days; nude mice bearing H69 xenografts) decreases tumoural vascularisation in vivo.Oblimersen (5-10 mg/kg; i.p.; daily (Monday to Friday), for 3 weeks) has antitumor efficacy in the subcutaneous tumor model.Animal Model:Male severe combined immunodeficient (SCID)-RAG2 mice
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; daily (Monday to Friday), for 3 weeks
Result:Inhibited tumor growth in a dose-dependent manner.
体外研究：
Oblimersen (500 nM; 72 hours; human small-cell lung cancer cell lines H69) decreases BCL-2 protein expression in vitro.Oblimersen (500 nM; 72 hours; human small-cell lung cancer cell lines H69) increases radiation-induced apoptosis.
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