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编 号：F708329
分子式：C53H82FNO17
分子量：1024.21
分子式：C53H82FNO17
分子量：1024.21
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CAS No: 1809266-03-2
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生物活性：
ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
体内研究：
ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.Animal Model:Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites.
Dosage:150 mg/kg.
Administration:PO once daily for 14 days started at 14 weeks post infection (pti).
Result:Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reducedby >99.9% in the recovered female adult worms.Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.
ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
体内研究：
ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.Animal Model:Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites.
Dosage:150 mg/kg.
Administration:PO once daily for 14 days started at 14 weeks post infection (pti).
Result:Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reducedby >99.9% in the recovered female adult worms.Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.
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