产品
编 号：F705671
分子式：C19H17Cl2NO3
分子量：378.25
分子式：C19H17Cl2NO3
分子量：378.25
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CAS No: 174185-16-1
产品详情
生物活性：
FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss.
体内研究：
FR-167356 (200 mg/kg; 口服; 每天, 持续 10 天; 具有 B16-F10 异种移植物的雄性 C57BL/6 小鼠) 抑制肿瘤生长并降低 MMP9 表达。FR-167356 (200 mg/kg; 口服; 每天, 持续 10 天; 具有 B16-F10 异种移植物的雄性 C57BL/6 小鼠) 与未处理组相比减少骨转移。Animal Model:male C57BL/6 mice with B16-F10 xenografts
Dosage:200 mg/kg
Administration:Oral administration; daily, for 10 days
Result:Reduced the expression of MMP9 and reduced bone metastasis.
FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss.
体内研究：
FR-167356 (200 mg/kg; 口服; 每天, 持续 10 天; 具有 B16-F10 异种移植物的雄性 C57BL/6 小鼠) 抑制肿瘤生长并降低 MMP9 表达。FR-167356 (200 mg/kg; 口服; 每天, 持续 10 天; 具有 B16-F10 异种移植物的雄性 C57BL/6 小鼠) 与未处理组相比减少骨转移。Animal Model:male C57BL/6 mice with B16-F10 xenografts
Dosage:200 mg/kg
Administration:Oral administration; daily, for 10 days
Result:Reduced the expression of MMP9 and reduced bone metastasis.
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