产品
编 号：F702466
分子式：C27H38BrN3O6S
分子量：612.58
分子式：C27H38BrN3O6S
分子量：612.58
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 166038-00-2
产品详情
生物活性：
BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity.
体内研究：
GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior. BrBzGCp2 pre-treatment decreases seizure duration.BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels.BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABAA receptor activation.BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice.Animal Model:Male CD-1 mice.
Dosage:50 mg/kg.
Administration:IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured)
Result:Allowed MG levels to accumulate for 2 hours
BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity.
体内研究：
GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior. BrBzGCp2 pre-treatment decreases seizure duration.BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels.BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABAA receptor activation.BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice.Animal Model:Male CD-1 mice.
Dosage:50 mg/kg.
Administration:IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured)
Result:Allowed MG levels to accumulate for 2 hours
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